has part realizes has specified input has specified output characteristic of function ChIP-seq assay cross linking DNA sequence data chromatin immunoprecipitation with exonuclease sequencing assay chromatin immunoprecipitation with exonuclease sequencing assay Rhee et al. Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution. Cell. 2011 Dec;147(6):1408-19. [PMID:22153082] Jie Zheng Venkat Malladi PMID:22153082 A ChIP-seq assay which uses immunoprecipitation to isolate protein bound DNA followed by an exonuclease step to degrade DNA that is not protein bound to provide greater resolution of the DNA binding site Chris Stoeckert ChIP-exo assay Bjoern Peters sonicator specific enzymatic cleavage metadata complete