bisulfite sequencing assay MethylC-Capture sequencing assay MethylC-Capture sequencing assay MethylC-Capture Sequencing approach was introduced as a cost-effective and customizable alternative method for large-scale interrogation of functionally-active methylomes while simultaneously providing genetic variation information in a proof-of-concept epigenome-wide association study of 72 obese individuals, identifying novel disease-associated variants. A bisulfite sequencing assay in which a whole-genome sequencing library is prepared, bisulfite converted and amplified, followed by a capture enriching for targeted bisulfite-converted DNA fragments that are are subsequently identified by DNA sequencing. David Bujold Chris Stoeckert Capture Methylome MethylC-Capture Sequencing MCC-Seq PMID:26021296 ready for release