realizes has specified input characteristic of function intracellular electrophysiology recording assay patch clamp device patch clamp assay url:http://www.annualreviews.org/doi/pdf/10.1146/annurev.ph.46.030184.002323 Gully Burns patch clamp assay ECO:0006012 url:https://en.wikipedia.org/wiki/Patch_clamp An intracellular electrophysiology assay where a glass micropipette is sealed to the surface of the cell membrane as a recording electrode to study ion channel activity. The key distinction of this technique is the electrical resistance of the seal between the cell membrane and the pipette is of the order 10-100 gigaohms, permitting high-resolution current measurements over the cell membrane in several different standard configurations. metadata complete