endonuclease mediated mutagenesis TALEN mediated mutagenesis Equivalent to FlyBase term "TALEN" (FBcv:0003009) in the origin of mutation branch. TALEN mediated mutagenesis Susan Bello ORCID:orcid.org/0000-0003-4606-0597 An endonuclease mediated mutagenesis in which guide RNAs and transcription activator-like effector nucleases (TALENs) are used to introduce a mutation at a specific location in the genome. url:https://pubmed.ncbi.nlm.nih.gov/23664777/ We designed transcription activator-like effector nucleases (TALENs) and a single-stranded oligo (ssOligo) donor template to edit the endogenous Actb locus within the mouse genome. PMID:30012594 metadata complete