DNA sequencing assay genome architecture mapping assay EFO:0009987 GAM A DNA sequencing assay designed to analyze 3D chromatin structure without relying on digestion and ligation. The procedure involves cryosectioning samples in random orientation, and then single nuclear profiles are isolated by laser microdissection. Each nuclear profile then undergoes high-throughput sequencing, and subsequent analysis can generate a matrix of inferred proximity between genomic regions. https://github.com/obi-ontology/obi/issues/1472 CFDE-4DN Suvarna Nadendla PMID:28273065 genome architecture mapping assay Michelle Giglio metadata complete