has_biological_process has_compartment has_transporter has_biochemical_parameter has_physicochemical_parameter has_physiological_parameter has_route_of_exposure excretion physiologically based pharmacokinetic model body mass index bodyweight height surface area assigned race cardiac output rate blood flow rate to stomach fraction of blood flow to stomach blood flow rate to intestine fraction of blood flow to intestine blood flow rate to small intestine fraction of blood flow to small intestine blood flow rate to large intestine fraction of blood flow to large intestine blood flow rate to pancreas fraction of blood flow to pancreas blood flow rate to liver fraction of blood flow to liver blood flow rate to kidney fraction of blood flow to kidney blood flow rate to muscle fraction of blood flow to muscle blood flow rate to heart fraction of blood flow to heart blood flow rate to fat fraction of blood flow to fat blood flow rate to gonad fraction of blood flow to gonad blood flow rate to skin fraction of blood flow to skin blood flow rate to bone fraction of blood flow to bone blood flow rate to brain fraction of blood flow to brain blood flow rate to spleen fraction of blood flow to spleen blood flow rate to lung fraction of blood flow to lung blood flow rate to poorly perfused fraction of blood flow to poorly perfused blood flow rate to richly perfused fraction of blood flow to richly perfused blood flow rate to restbody fraction of blood flow to restbody blood flow rate to gall bladder fraction of blood flow to gall bladder blood flow rate to portal vein fraction of blood flow to portal vein blood flow rate to lymph fraction of blood flow to lymph amount of metabolized fraction of blood flow to stratum corneum fraction of exposed skin fraction of unexposed skin arterial blood flow rate venous blood flow rate glomerular filtration rate volume of stomach fraction of stomach volume of intestine fraction of intestine volume of small intestine fraction of small intestine volume of large intestine fraction of large intestine volume of pancreas fraction of pancreas volume of liver fraction of liver volume of kidney fraction of kidney volume of muscle fraction of muscle volume of heart fraction of heart volume of fat fraction of fat volume of gonad fraction of gonad volume of skin fraction of skin volume of bone fraction of bone volume of brain fraction of brain volume of spleen fraction of spleen volume of lung fraction of lung volume of poorly perfused fraction of poorly perfused volume of richly perfused fraction of richly perfused volume of plasma fraction of plasma volume of rest body fraction of rest body volume of stratum corneum with respect to blood volume of blood volume of exposed skin volume of unexposed skin volume of stratum corneum exposed volume of unexposed stratum corneum fraction alveolar volume volume of gall bladder fraction of gall bladder volume of portal vein fraction of portal vein volume of lymph fraction of lymph arterial volume venous volume molecular weight lipophillicity distribution coefficient dissolution in two phase system logarithmic solubility water solubility acid dissociation constant basic dissociation constant physiological charge hydrogen acceptor count hydrogen donor count rotatable bond count absorption absorption rate constant gut absorption rate constant intestine gastric emptying rate enterohepatic recirculation specific intestinal permeability distribution process volume of distribution fraction unbound gut fraction unbound stomach fraction unbound intestine fraction unbound pancreas fraction unbound liver fraction unbound kidney fraction unbound muscle fraction unbound heart fraction unbound fat fraction unbound gonad fraction unbound skin fraction unbound bone fraction unbound spleen fraction unbound lung fraction unbound enterocytes gut plasma partition coefficient stomach plasma partition coefficient intestine plasma partition coefficient pancreas plasma partition coefficient liver plasma partition coefficient kidney plasma partition coefficient muscle plasma partition coefficient heart plasma partition coefficient fat plasma partition coefficient gonad plasma partition coefficient skin plasma partition coefficient bone plasma partition coefficient spleen plasma partition coefficient lung plasma partition coefficient rich perfused plasma partition coefficient poor perfused plasma partition coefficient skin stratum corneum partition coefficient air plasma partition coefficient blood:plasma ratio catalytic rate constant maximum rate in intestine Michaelis constant intestine maximum rate in liver Michaelis constant liver dissociation constant oatp abcc3 abcc2 degradation rate constant inhibition constant fecal clearance rate sweat clearance rate urinary clearance rate biliary clearance rate hepatic clearance rate intrinsic clearance rate fecal elimination rate constant renal elimination rate constant oral exposure dermal exposure inhalation exposure intravenous bolus exposure intravenous infusion exposure intramuscular exposure intraarterial exposure intrathecal exposure subcutaneous exposure nasal exposure transdermal exposure ocular exposure reference human data set permeability limited pbpk 0000-0001-8345-1349 0000-0002-9795-5967 A physiologically based pharmacokinetic model that considers the permeability across membranes as a limiting factor for compound distribution. maximum rate of basolateral transporter in vitro Michaelis constant baso maximum rate of apical transporter in vitro Michaelis constant apical influx constant efflux rate constant plasma space endosomal space compartment interstitial space effective permeability central compartment peripheral compartment elimination fetus lifestage infant lifestage toddler lifestage child lifestage teenager lifestage adolescent lifestage adult lifestage middle age lifestage old age lifestage pediatric lifestage geriatric lifestage cerebrospinal fluid volume cranial cerebrospinal fluid volume brain mass spinal cerebrospinal fluid flow rate cranial cerebrospinal fluid flow rate volume of hippocampus volume of frontal cortex volume of cerebrum volume of cerebellum blood flow rate to hippocampus blood flow rate to frontal cortex blood flow rate to cerebrum blood flow rate to cerebellum hippocampus brain partition coefficient cerebrum brain partition coefficient cerebellum brain partition coefficient frontalcortex brain partition coefficient apparent permeability cerebrum to rest of brain apparent permeability cerebellum to rest of brain apparent permeability hippocampus to rest of brain apparent permeability cortex to rest of brain fetoplacental volume volume of fetus volume of placenta volume of amniotic fluid volume of liver fetus volume of brain fetus volume of kidney fetus volume of rest body fetus fetoplacental blood flow rate fetal cardiac output rate blood flow rate to liverfetus blood flow rate to kidneyfetus blood flow rate to brain fetus blood flow rate to restbody fetus gestational age gestational week maximum rate in fetus amniotic transfer coefficient liverfetus plasma partition coefficient brainfetus plasma partition coefficient kidneyfetus plasma partition coefficient restbodyfetus plasma partition coefficient bladder compartment extrathoracic compartment thoracic compartment fraction of blood flow to duodenum fraction of blood flow to jejunum fraction of blood flow to ileum fraction of blood flow to colon fraction of blood flow to cecum blood flow rate to duodenum blood flow rate to jejunum blood flow rate to ileum blood flow rate to colon blood flow rate to cecum fraction of duodenum fraction of jejunum fraction of ileum fraction of colon fraction of cecum volume of duodenum volume of jejunum volume of ileum volume of colon volume of cecum bile salt effect solubilization ratio mean precipitation time diffusion coefficient particle density particle radius intestinal transit time milk plasma ratio fraction unbound milk daily milk intake phmilk milk plasma partition coefficient rest of body compartment arterial plasma venous plasma compartment richly perfused tissue compartment poorly perfused tissue compartment adipose compartment blood compartment bone marrow compartment brain compartment skin compartment endocrine gland compartment hair compartment heart compartment mammary gland compartment muscle compartment nail compartment pancreas compartment plasma compartment reproductive compartment spleen compartment barrier compartment fraction of filtrate fraction of gut fraction of mammary gland fraction of blood flow to filtrate fraction of blood flow to bone marrow fraction of blood flow to gut fraction of blood flow to mammary gland brain plasma partition coefficient mammary gland plasma partition coefficient restbody plasma partition coefficient tissue plasma partition coefficient urinary rate constant age in PBPK model volume of filtrate volume of bone marrow volume of gut volume of mammary gland volume of mass balance hematocrit volume cardiac output rate of plasma blood flow rate to filtrate blood flow rate to bone marrow blood flow rate to gut blood flow rate to mammary gland blood flow rate for mass balance urinary rate resorption maximum resorption octanol air partition coefficient arterial blood compartment digestive system compartment excreta compartment feces compartment urine compartment kidney compartment liver compartment lung compartment venous blood compartment absorption rate constant