has_biological_process has_compartment has_biochemical_parameter has_physiological_parameter has_route_of_exposure physiologically based pharmacokinetic model body mass index bodyweight height arterial blood flow rate venous blood flow rate volume of plasma fraction of plasma arterial volume absorption blood:plasma ratio urinary clearance rate renal elimination rate constant oral exposure intravenous bolus exposure intravenous infusion exposure one-compartment pbpk A physiologically based pharmacokinetic model that treats the entire body as a single, kinetically homogenous unit (central compartment). 0000-0002-9795-5967 0000-0001-8345-1349 elimination plasma compartment age in PBPK model cardiac output rate of plasma absorption rate constant