valid_for_go_annotation_extension valid_for_gocam causally upstream of, positive effect constitutively upstream of 2022-09-26T06:01:01Z https://wiki.geneontology.org/Constitutively_upstream_of p is constitutively upstream of q iff p is causally upstream of q, p is required for execution of q or a part of q, and the execution of p is approximately constant. Pascale Gaudet