part of has part lacks_part has plasma membrane part capable of capable of granulocyte monocyte progenitor cell CFU-GM colony forming unit granulocyte macrophage ZFA:0009251 https://cellxgene.cziscience.com/cellguide/CL_0000557 Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte/monocyte progenitor GMP Granulocyte monocyte progenitor cells (GMP cells), originating from hematopoietic stem cells in the bone marrow, are a critical intermediate in myeloid cell development. Positioned at a key differentiation juncture, these cells exhibit bidirectional potential, giving rise to both granulocyte and monocyte lineages. Their primary role is to generate mature granulocytes and monocytes, essential components of the body's innate immunity and inflammatory responses. Granulocytes, such as neutrophils, eosinophils, and basophils, contribute to the first line of defense against infections by migrating to the infection site and phagocytosing pathogens. Monocytes can differentiate into macrophages or dendritic cells, playing diverse roles in immune responses. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) CFU-C , Colony forming unit in culture A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. granulocyte/monocyte precursor granulocyte-macrophage progenitor myeloid cell CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor hematopoietic oligopotent progenitor cell bone marrow hematopoietic cell macrophage differentiation granulocyte differentiation Homo sapiens interleukin-3 receptor class 2 alpha chain transcription factor PU.1 CCAAT/enhancer-binding protein alpha erythroid transcription factor endothelial transcription factor GATA-2 bone marrow