has soma location has soma location capable of capable of expresses expresses has characterizing marker set interneuron VIP GABAergic cortical interneuron Vip GABAergic neuron The marker set VIP can identify the Human cell type VIP GABAergic cortical interneuron in the neocortex with a confidence of 0.855531344 (NS-Forest FBeta value). A transcriptomically distinct cortical GABAergic neuron that expresses the vasocactive intestinal polypeptide and that has its soma located in the cerebral cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip. VIP cortical interneuron VIP neuron This neuronal type is distinguished by its heterogeneous morphology and electrophysiological characteristics (Pronneke et al., 2015,2020; Apicella and Marchionni, 2022). Variations in morphology and firing patterns are observed in human cortical VIP interneurons. In a study by Lee et al., 2023, four distinct subtypes of VIP neurons were identified, each exhibiting unique morphologies, soma locations, and electrophysiological properties. These subtypes are defined according to their transcriptomic markers: LBH-VIP and CCD184-VIP, both of which display a bipolar morphology with axons and dendrites extending across cortical layers; and SY16-VIP and ADAMTSL1-VIP, characterized by a dendritic arbor that spreads horizontally within the same layer as the soma (Lee et al., 2023). Disruption or malfunction of VIP cortical interneuron is implicated in neurodevelopmental disorders such as Rett Syndrome and Dravet Syndrome (Goff and Goldberg 2021). VIP type VIP-Expressing GABAergic Neuron VIP interneuron Vip ILX:0770151 VIP-IN cortical VIP neuron caudal ganglionic eminence derived cortical interneuron gamma-aminobutyric acid secretion, neurotransmission Homo sapiens VIP peptides cerebral cortex