part of has part in taxon has primary input transmembrane receptor protein tyrosine kinase activity insulin receptor activity https://github.com/geneontology/go-ontology/issues/23056 https://github.com/geneontology/go-ontology/issues/28520 Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. Reactome:R-HSA-74715 GO:0005009 insulin-activated receptor activity molecular_function EC:2.7.10.1 insulin receptor signaling pathway protein-hormone receptor activity signaling receptor activity insulin binding Eumetazoa preproinsulin