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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
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    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

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    <!-- http://purl.obolibrary.org/obo/RO_0018038 -->

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    <!-- http://purl.obolibrary.org/obo/CHEBI_22333 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_22333">
        <rdfs:label>alkylating agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_25223 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25223">
        <rdfs:label>methanesulfonate ester</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_28901 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_28901">
        <rdfs:label>busulfan</rdfs:label>
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                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50905"/>
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        <oboInOwl:hasRelatedSynonym>Mitostan</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Tetramethylene bis(methanesulfonate)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Myeloleukon</oboInOwl:hasRelatedSynonym>
        <ns4:IAO_0000115>A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.</ns4:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>Mielucin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>butane-1,4-diyl dimethanesulfonate</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>1,4-Butanediol dimethanesulfonate</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Bisulfex</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>busulfanum</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Mablin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Misulban</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>1,4-Dimethanesulfonoxybutane</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Myleran</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Busulfan</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>busulfano</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Leucosulfan</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>1,4-Bis(methanesulfonoxy)butane</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>1,4-Dimesyloxybutane</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>butane-1,4-diyl dimethanesulfonate</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>busulfan</oboInOwl:hasRelatedSynonym>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_35610 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35610">
        <rdfs:label>antineoplastic agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_41189 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_41189">
        <rdfs:label>butane-1,4-diol</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_50903 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50903">
        <rdfs:label>carcinogenic agent</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_50905 -->

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        <rdfs:label>teratogenic agent</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_67105 -->

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        <rdfs:label>insect sterilant</rdfs:label>
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