EC 5.99.1.2 (DNA topoisomerase) inhibitor topoisomerase I (EC 5.99.1.2) inhibitor EC 5.99.1.2 (topoisomerase I) inhibitors topoisomerase I inhibitors EC 5.99.1.2 inhibitor EC 5.99.1.2 (DNA topoisomerase) inhibitors topoisomerase I inhibitor chebi_ontology A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. DNA topoisomerase inhibitor EC 5.99.1.2 (topoisomerase I) inhibitor type I DNA topoisomerase inhibitor type I DNA topoisomerase inhibitors CHEBI:50276 topoisomerase I (EC 5.99.1.2) inhibitors EC 5.99.1.2 inhibitors DNA topoisomerase inhibitors topoisomerase inhibitor