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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_50683 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50683">
        <rdfs:label>EC 1.5.1.3 (dihydrofolate reductase) inhibitor</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_73913"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76863"/>
        <ns3:IAO_0000115>An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD&lt;small&gt;&lt;sup&gt;+&lt;/small&gt;&lt;/sup&gt; or NADP&lt;small&gt;&lt;sup&gt;+&lt;/small&gt;&lt;/sup&gt; as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).</ns3:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>dihydrofolate reductase inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>NADPH-dihydrofolate reductase inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>dihydrofolate reductase (EC 1.5.1.3) inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>DHFR inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>dihydrofolic reductase inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>tetrahydrofolate dehydrogenase inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>7,8-dihydrofolate reductase inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>folic acid reductase inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>folic reductase inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>dihydrofolate reductase (EC 1.5.1.3) inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>EC 1.5.1.3 inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>dihydrofolic acid reductase inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>DHFR inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>tetrahydrofolate dehydrogenase inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>folic reductase inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>EC 1.5.1.3 inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>NADPH-dihydrofolate reductase inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>dihydrofolic acid reductase inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>7,8-dihydrofolate reductase inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>CHEBI:50683</oboInOwl:id>
        <oboInOwl:hasRelatedSynonym>EC 1.5.1.3 (dihydrofolate reductase) inhibitors</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>dihydrofolate reductase inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>dihydrofolic reductase inhibitor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>folic acid reductase inhibitors</oboInOwl:hasRelatedSynonym>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_73913 -->

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        <rdfs:label>antifolate</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_76863 -->

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        <rdfs:label>EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor</rdfs:label>
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