has role antineoplastic agent immunosuppressive agent antifungal agent sphingoid hydroxy monocarboxylic acid myriocin thermozymocidin CHEBI:582124 chebi_ontology antibiotic ISP-I ISP-1 An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity. (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid antibiotic ISP-1 ISP-I (2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor alpha-amino fatty acid apoptosis inducer fungal metabolite