has role Hedgehog signaling pathway inhibitor dichlorobenzene aromatic ether dioxolane N-arylpiperazine P450 inhibitor cyclic ketal itraconazole itraconazole Oriconazole An <em>N</em>-arylpiperazine that is <i>cis</i>-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a <em>p</em>-[(±)1-<em>sec</em>-butyl-5-oxo-1,5-dihydro-4<em>H</em>-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis. chebi_ontology Sporanox (TN) CHEBI:6076 Itraconazole Itrizole (TN) EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor conazole antifungal drug triazole antifungal drug