has role macrolide toxin oxabicycloalkane thiazolidinone cyclic hemiketal latrunculin A (+)-latrunculin A LAT-A CHEBI:43626 LATRUNCULIN A (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge <em>Latrunculia magnifica</em> and from the Fiji Islands sponge <em>Cacospongia mycofijiensis</em>. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. chebi_ontology NSC 613011 LatA (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one CHEBI:69136 actin polymerisation inhibitor