has role macrolide lactam anticoronaviral agent geroprotector ether organic heterotricyclic compound antineoplastic agent secondary alcohol immunosuppressive agent antibacterial drug cyclic ketone cyclic acetal mTOR inhibitor bacterial metabolite antibiotic antifungal drug sirolimus Antibiotic AY 22989 rapamycin A macrolide lactam isolated from <em>Streptomyces hygroscopicus</em> consisting of a 29-membered ring containing 4 <i>trans</i> double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. CHEBI:67812 (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone CHEBI:9168 Sirolimus chebi_ontology (-)-Rapamycin CHEBI:45276