striatum neuron GABA-Chol neuron GABAergic interneuron striatal cholinergic-GABAergic neuron A large aspiny interneuron of the striatum that serves as the principal intrinsic source of acetylcholine while simultaneously releasing GABA. It is defined by coexpression of cholinergic markers (ChAT and VAChT/Slc18a3) and GABAergic markers (GAD65/Gad2 and VGAT/Slc32a1) (Lozovaya et al., 2018). This MGE-derived neuron maintains Lhx6 expression associated with dual-transmitter identity (Fragkouli et al., 2009; Marin et al., 2000). Morphologically, it possesses a large soma (20–50 μm diameter), 2–4 thick aspiny dendrites extending radially ~1 mm, and locally ramified axons with hundreds of thousands of varicosities (Wilson et al., 1990; Lim et al., 2014).