directly develops from capable of oligodendrocyte myelin-forming oligodendrocyte mature myelinating oligodendrocyte A post-mitotic oligodendrocyte derived from a myelin-forming oligodendrocyte (MFOL). A mature Myelinating Oligodendrocyte is a fully differentiated cell that is actively engaged in myelination. In addition to high expression of canonical myelin genes (e.g., Mbp, Plp1, Mog), a MOL can be distinguished by the expression of stage-enriched genes Grm3, Klk6, Ptgds, Anxa5, and Hopx in mice. These markers reflect the functional specialization of a mature oligodendrocyte, including roles in signalling, lipid metabolism, and myelin maintenance. central nervous system myelin formation ectoderm-derived structure