negatively regulates negatively regulates biological_process negative regulation of metabolic process negative regulation of macromolecule metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. GO:0010605 biological_process macromolecule metabolic process regulation of macromolecule metabolic process