negatively regulates negatively regulates catalytic activity negative regulation by symbiont of host catalytic activity downregulation by symbiont of host enzyme activity inhibition of host enzyme activity biological_process down regulation by symbiont of host enzyme activity inhibition by symbiont of host enzyme activity negative regulation by symbiont of host enzyme activity down-regulation by symbiont of host enzyme activity GO:0052053 Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. modulation by symbiont of host molecular function negative regulation by symbiont of host molecular function modulation by symbiont of host catalytic activity negative regulation of catalytic activity in other organism involved in symbiotic interaction