negatively regulates negatively regulates molecular_function modulation by symbiont of host molecular function negative regulation by symbiont of host molecular function inhibition of host protein function downregulation by symbiont of host protein function negative regulation by symbiont of host protein function down regulation by symbiont of host protein function GO:0052056 biological_process down-regulation by symbiont of host protein function Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of host proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. inhibition by symbiont of host protein function negative regulation of molecular function in other organism involved in symbiotic interaction