preceded by has_specified_output is_specified_output_of executes investigation q-value regression analysis method parallel group design factorial design acute toxicity study Orlaith Burke Alejandra Gonzalez-Beltran Philippe Rocca-Serra acute toxicity study acute toxicity study is an investigation which use interventions organized according to a factorial design and a parallel group design to observe the effect of use of high dose xenobiotics in animal models or cellular models between group comparison statistical test p-value