part_of long term potentiation LTP Long-term potentiation Long-term potentiation (LTP) is a strengthening of the synapse that can last from hours to days and months. It is thought to underlie information storage and constitute the cellular basis of learning and memory. LTP engages numerous cascades of events on either side of the synapse and is accompanied by changes in gene expression. PW:0000060 long-term synaptic potentiation pathway excitatory synaptic transmission pathway