cardiovascular system disease pathway metabolic syndrome X pathway PW:0000174 The metabolic syndrome is a multiphenotypic condition with concurrent features of several diseases and metabolic abnormalities. Insulin resistance, obesity and hypertension are considered risk factors. Alterations in lipid, glucose and cholesterol metabolic pathways, among others, can contribute to the multifactorial metabolic syndrome and the conditions associated with it. abdominal obesity-metabolic syndrome 1 pathway dysmetabolic syndrome X pathway metabolic syndrome pathway pathway metabolic disease pathway