phosphatidylinositol 3-kinase-Akt signaling pathway PI3K Cascade PI3K-Akt signaling pathway PI3K/AKT Signaling PW:0000232 The phosphatidylinositol 3-kinase-Akt signaling pathway, involving PI3K class I enzymes, particularly class IA, controls various processes such as cell growth, proliferation and survival. Class IA enzymes couple to receptor tyrosine kinases or their adaptors; class IB couple to G-protein-coupled receptors mainly via Galphai. Members of the Akt family of protein kinases are activated downstream of class I PI3Ks and collectively (Akt1, 2, and 3) phosphorylate more than 70 cytoplasmic and nuclear substrates. Deregulation of the pathway has been linked to various forms of cancer. pathway phosphoinositide 3-kinase-Akt signaling pathway phosphatidylinositol 3-kinase class I signaling pathway serine/threonine-specific kinase mediated signaling pathway