growth factor signaling pathway insulin-like growth factor signaling pathway Insulin-like growth factor signaling plays important roles in cell growth and proliferation. Produced primarily by the liver in response to stimulation by growth hormone (GH), the proteins activate cognate receptors to prompt intracellular signaling pathways and cell growth in a variety of tissues. Deregulation of the pathway has been associated with various conditions, including cancer. PW:0000238 insulin-like growth factor receptor signaling pathway pathway peptide and protein hormone signaling pathway