prion disease pathway Gerstmann-Strussler syndrome, Gerstmann-Strussler-Scheinker syndrome pathway Gerstmann-Strussler syndrome, Gerstmann-Strussler-Scheinker syndrome - a group of rare prion diseases, of autosomal dominant inheritance but linked to different mutations of the prion protein gene. Common characteristics include cognitive and motor disturbances, the presence of multicentric amyloid plaques in the brain. Its manifestations include cerebellar ataxia and dementia, rigidity, tremor, memory loss and others, depending on the form of the condition. PW:0000266 pathway