pathway pertinent to protein folding, sorting, modification, translocation and degradation protein secretory pathway PW:0000280 The secretory pathway is the route by which secreted proteins travel from sites of biosynthesis and folding, modification and sorting, to their final destinations. It involves ER insertion where folding and quality control of folding take place, move to Golgi and trans-Golgi Network (TGN) where sorting and final modifications take place, exit from Golgi and vesicular transport and delivery to plasma membrane and extracellular space or the endosomal system via constitutive or regulated exocytosis. pathway