pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis altered regulatory pathway altered pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis PW:0000290 Those pathways involved in and/or controlling DNA replication, cell cycle, DNA repair and preservation of genomic integrity, RNA and protein biosynthesis that deviate from what their normal course should be. Such aberrant pathways, alone or in combination with other pathways underlie various diseases. pathway