altered growth factor signaling pathway transforming growth factor-beta superfamily mediated signaling pathway altered transforming growth factor-beta superfamily mediated signaling pathway PW:0000335 Those TGF-beta superfamily mediated signaling pathways that deviate from what their normal course should be. Alone or in combination with other pathways they underlie many conditions such as pulmonary hypertension and various types of cancer. altered TGF-beta superfamily mediated signaling pathway pathway