part_of oxygen homeostasis pathway hypoxia inducible factor pathway HIF pathway PW:0000360 Regulation of gene expression by Hypoxia-inducible Factor The hypoxia inducible transcription factor is activated in response to hypoxic conditions to promote the expression of many genes that play important roles in glucose and energy metabolism, angiogenesis and erythropoiesis. pathway transcription factor mediated signaling pathway transcription pathway via transcription factor mediated signaling