cellular detoxification pathway nuclear factor, erythroid 2 like 2 signaling pathway Nfe2l2 signaling pathway Nrf2 signaling pathway Nuclear factor, 2 like 2 (Nfe2l2, also known as Nrf2) signaling pathway is one of the most important regulator of antioxidant and/or electrophilic stress responses. Upon activation, Nfe2l2 induces the expression of antioxidant, xenobiotic metabolism, and cytoprotective genes, among others. Deregulation of the pathway has been associated with various conditions, including neurodegeneration and cancer. PW:0000369 pathway oxidative stress response pathway transcription factor mediated signaling pathway xenobiotic metabolic pathway transcription pathway via transcription factor mediated signaling