protein modification pathway via conjugation with ubiquitin and ubiqutin-like molecules neddylation pathway A pathway of protein modification via conjugation with Nedd8 - a ubiquitin-like protein. All Nedd8 targets appear to be members of the cullin family. Cullins participate in the assembly of various E3 ligase complexes. The neddylation pathway is important for embryogenesis and cell cycle control in metazoa, embryonic development in animals. Neddylation PW:0000435 pathway protein neddylation