part_of coagulation cascade pathway Formation of Fibrin Clot (Clotting Cascade) PW:0000474 The coagulation cascade is the series of events proceeding via the tissue factor (extrinsic) or the contact activation (intrinsic) pathway and converging in the formation of fibrin clots. Several anticoagulation systems are in place to modulate the pathway. The coagulation cascade and the complement pathway of immune responses are connected in a cross talk. blood coagulation, fibrin clot formation pathway secondary hemostasis hemostasis pathway