androgen signaling pathway Androgens are C19 steroids that constitutes the male sex hormones. They are also the precursors of female sex hormones, the estrogens. Testosterone and its more potent metabolite, dihydrotestosterone bind to androgen receptors to then translocate to the nucleus and activate the transcription of target genes. Many regulators, both activators and repressors, have been identified. Upregulation of receptor activity has been implicated in prostate cancer. PID:200105 PW:0000564 pathway sex steroids signaling pathway transcription factor mediated signaling pathway transcription pathway via transcription factor mediated signaling