digestive system cancer pathway pancreatic cancer pathway KEGG:05212 PW:0000626 Pancreatic cancer, a malignant tumor of the pancreas, has both genetic and predisposing factors. Deregulated pathways, such as TGF-B, PI3K-Akt or RAF/MEK/ERK, have been implicated in the development of pancreatic cancer. malignant neoplasm of pancreas pathway pancreatic neoplasm pathway pathway endocrine gland cancer pathway