phosphatase mediated signaling pathway tyrosine-specific phosphatase mediated signaling pathway PW:0000654 The protein tyrosine phosphatase superfamily exerts essential roles in signaling pathways. The coordinated interplay of tyrosine kinase mediated phosphorylation and tyrosine phosphatase mediated dephosphorylation of substrates shapes the functional topology of signaling networks. The PTP superfamily is composed of four families. pathway