mismatch repair pathway altered single-strand DNA repair pathway altered mismatch repair pathway A mismatch repair pathway that deviates from what its normal course should be. Mutations in several genes in the pathway have been implicated in cases of colorectal cancer, primarily the inherited forms. To a lesser extent they are found in other types of cancer, such as type 1 endometrial cancer. Diseases of Mismatch Repair (MMR) PW:0000668 altered MMR pathway pathway