altered peptide and protein hormone signaling pathway altered glucose homeostasis pathway glucagon signaling pathway altered glucagon signaling pathway A glucagon signaling pathway that deviates from what its normal course should be. Glucagon signaling counteracts the signaling of insulin and the potential exists that an alteration of glucagon signaling has a role to play in diabetes type 2. Serum glucagon is elevated in patients with the disease; the mechanisms leading to and the consequences of elevated glucagon remain to be established. PW:0000679 pathway