extrinsic apoptotic pathway tumor necrosis factor superfamily mediated signaling pathway FasL mediated signaling pathway Fas ligand binding to its receptor triggers a conformational change that allows the receptor to assemble a signaling complex known as DISC, followed by recruitment of pro-caspase-8 and activation of caspase-3 and -7. It is believed that Fas-mediated signaling to elicit apoptosis follows two routes. Fas signaling pathway FasL/ CD95L signaling PW:0000681 pathway