vasopressin signaling pathway vasopressin signaling pathway via receptor type 2 2009-11-03T08:39:15Z KEGG:04962 PW:0000713 SMP:00322 Vasopressin signaling via receptor type 2 plays a central role in water homeostasis by regulating the translocation of Aqp2 channel. The receptor couples to Gs alpha subunit leading to activation of adenylyl cyclase, production of cyclic AMP and triggering of protein kinase A (PKA) signaling pathway. PKA regulates both the translocation and the expression of the channel. pathway vpetri