forkhead signaling pathway forkhead class O signaling pathway 2009-11-30T01:42:57Z FoxO signaling pathway PW:0000717 The signaling pathway mediated by the FoxO subgroup of forkhead family of transcription factors regulates cell cycle and survival via the expression of its target genes. FoxO pathway is negatively regulated by PI3K-Akt pathway downstream of insulin signaling. It is positively regulated by the Jnk pathway of stress activated MAPK cascade. pathway vpetri