p53 signaling pathway altered transcription factor mediated signaling pathway altered p53 signaling pathway 2009-11-30T03:43:14Z A p53 signaling pathway that deviates from what its normal course should be. Due to its central role at the intersection of many cellular pathways, disturbance of p53 network can have far-reaching negative consequences. The tumor suppressor Tp53 gene is frequently mutated in cancer. PW:0000720 pathway vpetri altered transcription pathway via transcription factor mediated signaling altered stress response pathway