anti-diabetic drug pathway 2010-01-18T03:43:49Z PW:0000723 The pharmacokinetics and pharmacodynamics of anti-diabetic drugs such as repaglinide, nateglinide and sulfonylurea - inhibitors of ATP-dependent potassium channel. By blocking the channel they stimulate insulin secretion to lower blood glucose level. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri alimentary tract and metabolism drug pathway