gemcitabine pathway gemcitabine pharmacokinetics pathway 2010-03-17T08:18:10Z PW:0000759 SMP:00603 The pathway of processing - absorption, distribution, metabolism or elimination of gemcitabine. Gemcitabine is a cytidine analogue administered as a prodrug for the treatment of certain cancers. The diphosphate form is an inhibitor of ribonucleotide reductases, essential enzymes of deoxyribonucleotide synthesis. Genetic variations can result in changes in the availability of the drug. pathway vpetri