gemcitabine pathway gemcitabine pharmacodynamics pathway 2010-03-17T08:27:03Z PW:0000760 SMP:00446 The pathway of gemcitabine-target interaction and of the biochemical or physiological responses to drug. Gemcitabine is a cytidine analogue that is administered as a prodrug for the treatment of certain types of cancer. The diphosphate form is an inhibitor of ribonucleotide reductases, essential enzymes of deoxyribonucleotide synthesis. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri