interleukin-1 family mediated signaling pathway interleukin-1 signaling pathway 2011-08-29T11:15:28Z Il-1 signaling pathway Interleukin-1 signaling Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin-1alpha and beta. PW:0000883 interleukin-1-mediated signaling pathway pathway vpetri pro-inflammatory cytokine mediated pathway