methotrexate drug pathway 2012-04-27T01:27:25Z MTX drug pathway PW:0000930 The pharmacokinetics and pharmacodynamics of methotrexate (MTX), a polyglutamatable antifolate used in the treatment of cancers and autoimmune diseases. The impact of MTX on cancer and rheumatoid arthritis is thought to arise through distinct mechanisms and pharmacodynamics pathways. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri antineoplastic drug pathway immunosuppressant drug pathway